effects of regular swimming exercise on the pain threshold following withdrawal syndrome in morphine-dependent rats
نویسندگان
چکیده
introduction: nowadays opioids are gaining acceptance for the management of moderate to severe and chronic pain. in addition, a number of studies have shown that plasma levels of β-endorphin (βep) in exercise trained are higher than sedentary rats. in our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. methods: male wistar rats (250±20 g, n=24) were addicted by morphine sulfate 0.4mg/ml (for 21 days) and animals were submitted to swimming training, five days a week for 8 weeks, in which first 60 minutes for 3 weeks and then 90 minutes in two weeks and at the end 120 min for 3weeks. at the end of each stage of exercise protocol naloxan hydrochloride (3mg/kg.ip) was injected. tail-flick was used to assess the effect of training on nociceptive threshold. results: data showed that swimming aerobic exercise significantly increased pain threshold in trained control and addicted rats (p<0.05) while pain responses did not significantly change in sedentary control and addicted rats. conclusion: our results indicate that swimming training has analgesic property in morphine withdrawal-induced hyperalgesia in rats. therefore, it can be used for the treatment and/or management of painful conditions.
منابع مشابه
Effects of regular swimming exercise on the pain threshold following withdrawal syndrome in morphine-dependent rats
Introduction: Nowadays Opioids are gaining acceptance for the management of moderate to severe and chronic pain. In addition, a number of studies have shown that plasma levels of β-endorphin (βEP) in exercise trained are higher than sedentary rats. In our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. Methods: Male Wistar rats (2...
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Background & Aims: Many evidences show that regular resistance exercise training can increase activity and release of opioids in the CNS. Also it is known that as the body needs magnesium sulfate antagonist of N-methyl-D-aspartate receptor as a pain reliever, it increases resistance exercise. In this research, the effect of resistance exercise and oral magnesium sulfate on pain threshold o...
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عنوان ژورنال:
physiology and pharmacologyجلد ۱۵، شماره ۲، صفحات ۲۸۸-۲۹۴
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